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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Toxic shock syndrome toxin ： ウィキペディア英語版 Toxic shock syndrome toxin Toxic shock syndrome toxin (TSST) is a superantigen with a size of 22KDa〔 produced by 5 to 25% of ''Staphylococcus aureus'' isolates. It causes toxic shock syndrome (TSS) by stimulating the release of large amounts of interleukin-1, interleukin-2 and tumour necrosis factor. In general, the toxin is not produced by bacteria growing in the blood; rather, it is produced at the local site of an infection, and then enters the blood stream. ==Characteristics== TSST-1, a prototype superantigen secreted by a ''Staphylococcus aureus'' bacterium strain in susceptible hosts, acts on the vascular system by causing inflammation, fever, and shock.〔Todar, Kenneth. (2012). ("Bacterial Protein Toxins" ). ''Todar's Online Textbook of Bacteriology''. Madison, Wisconsin.〕 This bacterium strain that produces the TSST-1's can be found in any area of the body, but live mostly in the vagina of infected women. TSST-1 is a bacterial exotoxin found in patients who have developed toxic shock syndrome (TSS), which can be found in menstruating women or any man or child for that matter.〔Edwin, Chitra, Parsonnet, Jeffrey, Kass, Edward H. (December 1988). ("Structure-Activity Relationship of Toxic-Shock-Syndrome Toxin-1: Derivation and Characterization of Immunologically and Biologically Active Fragments". ) The Journal of Infectious Diseases 158(6): 1287.〕 One-third of all TSS cases have been found in men. This statistic could possibly be due to surgical wounds or any skin wound.〔Bushra, Joseph S. ("Toxic Shock Syndrome Causes" ). ''eMedicineHealth.com''. WebMD, Inc. Retrieved 3/28/12.〕 TSST-1 is the cause of 50% of non-menstrual and 100% of all menstrual TSS cases.〔McCormick, John K., Tripp, Timothy J., et al. (April 2012). ("Functional Analysis of the TCR Binding Domain of Toxic Shock Syndrome Toxin-1 Predicts Further Diversity in MHC Class II/Superantigen/TCR Ternary Complexes". ) The Journal of Immunology 171:185-1392.〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Toxic shock syndrome toxin」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.